Journal Articles & Preprints

Rett syndrome lifespan extension in mice via AI-guided ADAR editing
Savva YA, Booth BJ, Shumaker L, Fasnacht R, Burleigh SM, Jiang Y, Cao Y, Johnson B, Bagepalli LR, Golic F, Enger N, Feiring R, Sadowski A, Rich S, Lakshmanan A, Milani N, Chadwick EM, Hauskins C, Works MG, Huss DJ, Briggs AW, VanSchoiack AA.
Preprint, 2026. doi.org/10.64898/2026.06.23.734060
Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARs
Cao Y, Bagepalli LR, Savva YA, Collins SM, Adams K, Letizia AJ, Boysen J, Abiar A, Edwards SR, Bussema L, Burleigh SM, Shumaker L, Hause RJ, Booth BJ*, Jiang Y*. *corresponding authors.
Preprint, 2025. doi.org/10.64898/2025.12.18.695251
An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing
Byrne SM, Burleigh SM, Fragoza R, Jiang Y, Savva YA, Pabon R, Kania E, Rainaldi J, Portell A, Mali P, Briggs AW.
Nature Communications, 2025. doi.org/10.1038/s41467-025-60155-z
Generative machine learning of ADAR substrates for precise and efficient RNA editing
Jiang Y*, Bagepalli LR*, Banjanin BS, Savva YA, Cao Y, Guo L, Briggs AW, Booth B, Hause RJ. *equal contributions.
Preprint, 2024. doi.org/10.1101/2024.09.27.613923
B cell mobilization, dissemination, fine tuning of local antigen specificity and isotype selection in asthma
Ohm-Laursen L, Meng H, Hoehn KB, Nouri N, Jiang Y, Clouser C, Johnstone TG, Hause R, Sandhar BS, Upton NEG, Chevretton EB, Lakhani R, Corrigan CJ, Kleinstein SH, Gould HJ.
Frontiers in Immunology, 12: 702074, 2021. doi.org/10.3389/fimmu.2021.702074
High-Throughput Single-Cell Sequencing with Linear Amplification
Yin Y, Jiang Y, Lam KG, Berletch JB, Disteche CM, Noble WS, Steemers FJ, Camerini-Otero RD, Adey AC, Shendure JA.
Molecular Cell, 2019. doi.org/10.1016/j.molcel.2019.08.002
Anti-B-cell maturation antigen chimeric antigen receptor T cell function against multiple myeloma is enhanced in the presence of lenalidomide
Works M, Soni N, Hauskins C, Sierra C, Baturevych A, Jones JC, Curtis W, Carlson P, Johnstone TG, Kugler D, Hause RJ, Jiang Y, Wimberly L, Clouser CR, Jessup HK, Sather B, Salmon RA, Ports MO.
Molecular Cancer Therapeutics, 2019. doi.org/10.1158/1535-7163.MCT-18-1146
Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated
Ibarra-Soria X, Nakahara TS, Lilue J, Jiang Y, Trimmer C, Souza MA, Netto PH, Ikegami K, Murphy NR, Kusma M, Kirton A, Saraiva LR, Keane TM, Matsunami H, Mainland JD, Papes F, Logan DW.
eLife, 6: e21476, 2017. doi.org/10.7554/eLife.21476
Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo
Jiang Y, Gong N, Hu X, Ni J, Pasi R, Matsunami H.
Nature Neuroscience, 18: 1446-1454, 2015. doi.org/10.1038/nn.4104
Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment
Jiang Y*, Li Y*, Tian H, Ma M, Matsunami H. *equal contributions.
Nature Communications, 6: 6448, 2015. doi.org/10.1038/ncomms7448
Mammalian odorant receptors: functional evolution and variation
Jiang Y, Matsunami H.
Current Opinion in Neurobiology, 34: 54-60, 2015. doi.org/10.1016/j.conb.2015.01.014
Calreticulin: roles in cell-surface protein expression
Jiang Y, Dey S, Matsunami H.
Membranes, 4: 630-641, 2014. doi.org/10.3390/membranes4030630
Astringency: a more stringent definition
Jiang Y, Gong N, Matsunami H.
Chemical Senses, 39: 467-469, 2014. doi.org/10.1093/chemse/bju021
Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1
Chen B, Jiang Y, Zeng S, Yan J, Li X, Zhang Y, Zou W, Wang X.
PLoS Genetics, 6: e1001235, 2010. doi.org/10.1371/journal.pgen.1001235

Conference Proceedings & Abstracts

A Brain-Targeting AAV5-Based Capsid Recognizes the Transferrin Receptor of Both Humans and NHPs to Cross the Blood-Brain-Barrier in vivo
Dunn A, Jiang Y, Johnsen W, Lakshmanan A, Milani N, Burleigh S, Golic F, Shannon S, Johnson B, Rainaldi J, Mali P, Hauskins C, VanSchoiack A, Briggs A, Sullivan R.
American Society of Gene & Cell Therapy (ASGCT) Annual Meeting, Boston, 2026 (accepted; to be presented).
Systemically delivered AAV5-based capsid variants enable up to 88% targeted RNA editing in primate brain
Sullivan R, Stein K, Tome J, Dunn A, Richardson C, Rubin V, Cates E, Bazinet J, Lara M, Edwards S, Koday M, Kall S, Bussema L, Shannon S, Fliss P, Gniffke T, Lloyd R, Olson R, Adams H, Johnsen W, Salukhe I, Thuline E, Jiang Y, Read D, Sorg K, Han W, Banjanin B, Kania E, Johnson B, Park-Oates M, Hauskins C, Long T, Hause R, Briggs A.
Molecular Therapy, 33(4), 2025 (ASGCT Annual Meeting abstract).
Massive Diversity Capsid Screening and Machine Learning Identify Next-Generation AAV for Targeted Tissue Biodistribution
Packard TA, Stein KC, Cates EA, Bazinet JE, Han W, Jiang Y, Andrade MF, Long TJ, Huss DJ, Hause RJ, Briggs AW.
Molecular Therapy, 31(4): 178, 2023 (ASGCT Annual Meeting abstract).
Generative Machine Learning Enables De Novo Guide RNA Design for Precise RNA Editing
Jiang Y, Bagepalli L, Banjanin B, Rupp K, Savva Y, Booth B, Hause R.
Molecular Therapy, 31(4): 263–264, 2023 (ASGCT Annual Meeting abstract).
Engineering CNS-targeted AAV capsids from massively diverse libraries using machine learning
Huss DJ, Packard TA, Cates E, Lee M, Bazinet JE, Stein KC, Jiang Y, Andrade MFL, Long TJ, Vigneault F, Hause R, Briggs AW.
Human Gene Therapy, 33(23–24): A32–A33, 2022 (ESGCT Annual Congress abstract).
Engineering AAV Capsids with CNS-Targeted Biodistribution from Massively Diverse Libraries Using Machine Learning
Packard TA, Cates E, Bazinet J, Stein KC, Jiang Y, Lee M, Andrade MFL, Long TJ, Huss DJ, Hause R, Briggs AW.
Molecular Therapy, 30(4): 69, 2022 (ASGCT Annual Meeting abstract).
Characteristics of post-infusion chimeric antigen receptor (CAR) T cells and endogenous T cells associated with early and long-term response in lisocabtagene maraleucel (liso-cel)-treated relapsed or refractory (R/R) large B-cell lymphoma (LBCL)
Thorpe J, Jiang Y, Rytlewski JA, Kostic A, Kim Y, Peiser L.
Blood, 138: 3834, 2021 (ASH Annual Meeting abstract).
Treatment with CC-99282 enhances antitumor function of the anti-CD19 CAR T cell therapy lisocabtagene maraleucel (liso-cel)
Brahmandam A, Qin J, Kim S, Jiang Y, Barajas B, Carrancio S, Peiser L.
Journal for ImmunoTherapy of Cancer, 9(Suppl 2): A117, 2021 (SITC Annual Meeting abstract).
Effects of prior alkylating therapies on preinfusion patient characteristics and starting material for CAR T cell product manufacturing in late-line multiple myeloma
Rytlewski J, Madduri D, Fuller J, Campbell TB, Mashadi-Hossein A, Thompson EG, Jiang Y, Martin N, Sangurdekar D, Finney O, Bitter H, Agarwal A, Kaiser S, Hege K, Hause RJ Jr.
Blood, 136: 7–8, 2020 (ASH Annual Meeting abstract).
Treatment with Iberdomide Enhances Antitumor Function of the Anti-CD19 Chimeric Antigen Receptor (CAR) T Cell Therapy Lisocabtagene Maraleucel (liso-cel)
Qin J, Jiang Y, Barajas B, Kasibhatla S, Ports M.
Molecular Therapy, 28(4): 499–500, 2020 (ASGCT Annual Meeting abstract).
Defined cell composition and precise control over JCAR017 dose enables identification of relationships between chimeric antigen receptor T cell product attributes, pharmacokinetics, and clinical endpoints in non-Hodgkin lymphoma
Larson RP, Devries T, Jiang Y, Hause RJ, Getto R, Christin B, Yee NK, Bowen M, Weber C, Li D, Albertson T, Sutherland CL, Ramsborg CG.
American Association for Cancer Research (AACR) Annual Meeting, 2018.
Inhibiting TGFβ signaling in CAR T-cells may significantly enhance efficacy of tumor immunotherapy
Vong Q, Nye C, Hause RJ, Clouser C, Jones J, Burleigh S, Borges CM, Chin SY, Marco E, Barrera L, Da Silva J, Harbinski F, Giannoukos G, Dhanapal V, Jiang Y, Salmon R, Wilson CJ, Myer VE, Welstead GG, Bond CJ, Sather BD.
American Society of Hematology (ASH) 59th Annual Meeting, 2017.
Lenalidomide enhances anti-BCMA chimeric antigen receptor T cell function against multiple myeloma
Works M, Soni N, Hauskins C, Sierra C, Baturevych A, Jones J, Curtis W, Johnstone T, Kugler D, Jiang Y, Hause RJ, Sather BD, Salmon R, Ports M.
American Society of Hematology (ASH) 59th Annual Meeting, 2017.
A syngeneic mouse model of CAR-T mediated toxicity and neuroinflammation
Chadwick E, Noll A, Jiang Y, Hause RJ, Ponce R, Levitsky H, Salmon R.
The Society for Immunotherapy of Cancer's (SITC) 32nd Annual Meeting, 2017.
IDO1-mediated tryptophan depletion potently inhibits CAR-T functionality as part of a CAR-T driven adaptive immune resistance response in the tumor microenvironment
Thomas EP, Jessup HK, Qin J, Jiang Y, Swanson C, Baturevych A, Swenson S, Prentice K, Hause RJ, Levitsky H, Ports M.
The Society for Immunotherapy of Cancer's (SITC) 32nd Annual Meeting, 2017.
Discovery of rare T cell receptors of therapeutic value by simultaneous detection of sequence, antigen specificity and cell phenotype from millions of single cells in emulsion
Goldfless SJ, Croft A, Brandt CS, Jeffery EW, Connor KL, Clouser CR, Jiang Y, Johnstone TG, Koppstein D, Nguyen H, Peper H, Toy D, Sissons J, Hause RJ, Briggs AW, Vigneault F.
Keystone Symposia on Molecular and Cellular Biology, 2017.